Phenotypes Associated with This Genotype

Genotype
MGI:3690236

• Allelic Composition: Odf2^{Gt(RRO072)Byg}/Odf2^{Gt(RRO072)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:114574 )

• no homozygotes are found when E3.5 blastocyts are genotyped

reproductive system

transmission ratio distortion ( J:114574 )

• mutant allele is transmitted above Mendelian predicted level; heterozygous crosses (F1) transmit mutant allele more frequently than predicted (113 heterozygotes/139 total vs 26/139 wild-type offspring; <4:1 instead of 2:1)

• TRD is not apparent in backcrosses with F3 mice