Phenotypes Associated with This Genotype

Genotype
MGI:3690928

• Allelic Composition: Il4ra^tm1Fbb/Il4ra^tm2Fbb; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:114751 )

• mice succumb to Schistosoma infection in ~54 days

growth/size/body

weight loss ( J:114751 )

• progressive weight loss begins 6 weeks after S. mansoni infection; some animals lose 20% of original body weight

immune system

abnormal immune system physiology ( J:114751 )

• mice show a similar Th1 response to Il4ra-null mice and a Th2 response similar to wild-type in response to Schistosoma infection

abnormal macrophage physiology ( J:114751 )

• livers show impaired alternative macrophage activation compared to wild-type

granulomatous inflammation ( J:114751 )

• granulomas are similar to wild-type, but slightly larger and less compact: intestinal granulomas show massive inflammatory cell infiltration

liver inflammation ( J:114751 )

• granulomas form

decreased susceptibility to parasitic infection ( J:114751 )

• mice develop protective immunity against Nippostrongylus brasiliensis, accompanied by Th2 development

increased susceptibility to parasitic infection ( J:114751 )

• mice show 100% mortality during acute infection by Schistosoma mansoni; mean survival time is 54 days

liver/biliary system

liver inflammation ( J:114751 )

• granulomas form

liver fibrosis ( J:114751 )

• level of fibrosis is similar to wild-type

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:114751 )

• during infection by N. brasiliensis, mice develop goblet cell hyperplasis

hematopoietic system

abnormal macrophage physiology ( J:114751 )

• livers show impaired alternative macrophage activation compared to wild-type

cellular

abnormal intestinal goblet cell morphology ( J:114751 )

• during infection by N. brasiliensis, mice develop goblet cell hyperplasis