Phenotypes Associated with This Genotype

Genotype
MGI:3691132

• Allelic Composition: Il23a^tm1Dnax/Il23a^tm1Dnax
• Genetic Background: B6.Cg-Il23a^tm1Dnax

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal granulocyte physiology ( J:111568 )

• fewer than expected granulocytes in the dermis of carcinogen treated skin and the levels of CSF3 are decreased compared to wild-type mice

abnormal CD8-positive, alpha-beta T cell physiology ( J:111568 )

• dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin

abnormal macrophage physiology ( J:111568 )

• fewer than expected macrophages in the dermis of carcinogen treated skin

abnormal interleukin level ( J:111568 )

• barely detectable levels of IL17 in the skin after carcinogen treatment unlike wild-type mice which express high levels of IL17

neoplasm

decreased incidence of tumors by chemical induction ( J:111568 )

• resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol

• however, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells

homeostasis/metabolism

abnormal interleukin level ( J:111568 )

• barely detectable levels of IL17 in the skin after carcinogen treatment unlike wild-type mice which express high levels of IL17

decreased incidence of tumors by chemical induction ( J:111568 )

• resistant to induction of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol

• however, there is an increase in the incidence of tumors following intradermal challenge with PDV squamous carcinoma cells

hematopoietic system

abnormal granulocyte physiology ( J:111568 )

• fewer than expected granulocytes in the dermis of carcinogen treated skin and the levels of CSF3 are decreased compared to wild-type mice

abnormal CD8-positive, alpha-beta T cell physiology ( J:111568 )

• dramatic increase in the number of cytotoxic CD8+ cells in the dermis and epidermis of carcinogen treated skin

abnormal macrophage physiology ( J:111568 )

• fewer than expected macrophages in the dermis of carcinogen treated skin