Phenotypes Associated with This Genotype

Genotype
MGI:3691146

• Allelic Composition: Itga3^tm1Son/Itga3^tm1Son; Tg(NPHS2-cre)295Lbh/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Glomerular basement membrane abnormalities and foot process effacement in kidneys of mildly affected Cd151^tm1Nki/Cd151^tm1Nki and Itga3^tm1Son/Itga3^tm1Son Tg(NPHS2-cre)295Lbh/0 mice

renal/urinary system

increased urine protein level ( J:114988 )

• exhibit massive proteinuria starting within the first week of age

albuminuria ( J:114988 )

podocyte foot process effacement ( J:114988 )

• complete effacement of podocyte foot processes in newborns

abnormal renal glomerulus basement membrane morphology ( J:114988 )

• glomerular basement membrane (GBM) is disorganized

• 6 week old mutants show widespread lamination and protrusions of the GBM

increased renal glomerulus basement membrane thickness ( J:114988 )

• abnormally thickened GBM with protrusions throughout the glomerulus

glomerulosclerosis ( J:114988 )

• kidneys contain partially sclerosed glomeruli

dilated proximal convoluted tubule ( J:114988 )

• dilated proximal tubules contain prominent protein casts

renal cast ( J:114988 )

• dilated proximal tubules contain prominent protein casts

pale kidney ( J:114988 )

• milky, discolored kidneys

homeostasis/metabolism

edema ( J:114988 )

• develop abdominal edema at 5-6 weeks of age

increased urine protein level ( J:114988 )

• exhibit massive proteinuria starting within the first week of age

albuminuria ( J:114988 )