Phenotypes Associated with This Genotype

Genotype
MGI:3694695

• Allelic Composition: Tap1^tm1Arp/Tap1^tm1Arp
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD8-positive, alpha-beta T cell number ( J:64177 , J:64349 )

• mice have very few mature CD8+ T cells (J:64177)

• CD8+ T cell number in periphery, and in thymus, is reduced (J:64349)

decreased cytotoxic T cell cytolysis ( J:64349 )

• mutants show a strong CTL response to syngeneic antigens from wild-type

abnormal dendritic cell antigen presentation ( J:64349 )

• CD8+ T cell responses to virus and protein antigen are reduced due to inability of dendritic cells to efficiently present antigen

• dendritic cells are unable to present ovalbumin via MHC class I molecules to an OVA-specific hybridoma

abnormal antigen presentation via MHC class I ( J:64349 )

• dendritic cells are unable to present ovalbumin via MHC class I molecules to an OVA-specific hybridoma

decreased level of surface class I molecules ( J:64177 , J:64349 )

• expression is only ~5% of wild-type (J:64177)

• CD8+ T cell number in periphery, and in thymus, is reduced (J:64349)

defective assembly of class I molecules ( J:64177 )

• most MHC class I molecules lack high-affinity peptides

defective intracellular transport of class I molecules ( J:64177 )

• MHC class I heterodimers lacking high-affinity peptides are retained in the endoplasmic reticulum and targeted for degradation in the cytosol

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:64177 , J:64349 )

• mice have very few mature CD8+ T cells (J:64177)

• CD8+ T cell number in periphery, and in thymus, is reduced (J:64349)

decreased cytotoxic T cell cytolysis ( J:64349 )

• mutants show a strong CTL response to syngeneic antigens from wild-type