Analysis Tools
liver/biliary system
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• resistant to Propionibacterium acnes induced liver granulomas
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immune system
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• highly susceptible to dextran sodium sulfate induced colitis
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• LPS-stimulated reactive oxygen intermediate (ROI) production by neutrophils is blocked compared to in similarly treated wild-type cells
• however, ROI production in response to PMA stimulation is normal
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• antibiotic treated mice infected with non-invasive Salmonella exhibit increased levels of Salmonella-specific IgA, but not IgG as compared to littermate controls
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• serum levels are elevated compared to wild-type
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• serum levels of IgG1 are elevated compared to wild-type
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• absence of rEA stimulated activation of macrophages unlike in wild-type controls
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• absence of rEA stimulated increase in cytokine and chemokine levels
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• decreased serum interferon alpha level following infection with Japanese encephalitis virus but not as severe as in mice homozygous for Ddx58tm1Aki
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• Propionibacterium acnes and Tlr2 ligands fail to induce TNF alpha
(J:103464)
• reduced TNF alpha production in response to both primary and secondary necrotic cells
(J:124334)
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• in response to LPS stimulation; however, detectable levels of TNF are present
• impairment is not as severe as in mice homozygous for both Myd88tm1Aki
and Traddtm1.1Mpa
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• profound defect in interferon alpha production in response to encephalomyocarditis virus in B220+ pDCs
(J:137522)
• absence of Eimeria tenella derived antigen (rEA) stimulated activation of dendritic cells unlike in wild-type controls
(J:174941)
• dendritic cells fail to produce higher levels of cytokines when stimulated with LPS, R848 or ODN2006 unlike wild-type cells
(J:174941)
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• flagellin stimulated primary intestinal epithelial cells display inhibited production of keratinocyte-derived cytokine and macrophage inflammatory protein 3 alpha
• IL-1beta fails to stimulate keratinocyte-derived cytokine production
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• bone marrow-derived plasmacytoid dendritic cells infected with a low dose of murine hepatitis virus A59 are not able to produce IFN-alpha compared to wild-type mice that show IFN-alpha production
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• antibiotic treated mice infected with non-invasive Salmonella exhibit decreased levels of interferon gamma in the mesenteric lymph nodes as compared to littermate controls
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• flagellin stimulated primary intestinal epithelial cells display inhibited production
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• resistant to myelin oligodendrocyte glycoprotein injection
• no apparent inflammation in the spinal cord
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• antibiotic treated mice infected with non-invasive Salmonella exhibit increased bacterial counts in the mesenteric lymph nodes as compared to littermate controls
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• modestly increased susceptibility of encephalomyocarditis virus
• but susceptibility to Japanese encephalitis virus is similar to controls
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hematopoietic system
| N |
• B cell apoptosis in Peyer's patch is not observed after bile duct ligation
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• LPS-stimulated reactive oxygen intermediate (ROI) production by neutrophils is blocked compared to in similarly treated wild-type cells
• however, ROI production in response to PMA stimulation is normal
|
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• antibiotic treated mice infected with non-invasive Salmonella exhibit increased levels of Salmonella-specific IgA, but not IgG as compared to littermate controls
|
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• serum levels are elevated compared to wild-type
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• serum levels of IgG1 are elevated compared to wild-type
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• absence of rEA stimulated activation of macrophages unlike in wild-type controls
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homeostasis/metabolism
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• resistant to STZ induced diabetes
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• more prone to hyperglycemia after low doses of streptozotocin
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• absence of rEA stimulated increase in cytokine and chemokine levels
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• decreased serum interferon alpha level following infection with Japanese encephalitis virus but not as severe as in mice homozygous for Ddx58tm1Aki
|
|
• Propionibacterium acnes and Tlr2 ligands fail to induce TNF alpha
(J:103464)
• reduced TNF alpha production in response to both primary and secondary necrotic cells
(J:124334)
|
|
• in response to LPS stimulation; however, detectable levels of TNF are present
• impairment is not as severe as in mice homozygous for both Myd88tm1Aki
and Traddtm1.1Mpa
|
neoplasm
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• resistant to Propionibacterium acnes induced liver granulomas
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respiratory system
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• bronchoalveolar protein levels are increased by ozone exposure
• ozone induced increase in bronchoalveolar cell counts are less than in controls at 3 hours but not 24 hours
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• ozone exposure does not lead to hyperresponsiveness
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endocrine/exocrine glands
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• beta cell volume as a percentage of pancreas volume is significantly reduced
• insulin content reduced
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• islet size is reduced
• number of islet is normal
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• increased beta cell apoptosis
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vision/eye
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• more proliferating cells in the retina at 6 days of age
• neuronal differentiation of precursors hearing/vestibular/ear
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digestive/alimentary system
| N |
• mice exhibit normal mucus production
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• mice exhibit a 100-fold higher mucosal bacterial loads compared with wild-type mice
• however, luminal bacterial loads are normal
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• flagellin stimulated primary intestinal epithelial cells display inhibited production of keratinocyte-derived cytokine, macrophage inflammatory protein 3 alpha, and IL-6
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• highly susceptible to dextran sodium sulfate induced colitis
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