Phenotypes Associated with This Genotype

Genotype
MGI:3695291

• Allelic Composition: Pctp^tm1Bor/Pctp^tm1Bor
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

gallstones ( J:115285 )

• Background Sensitivity: on a lithogenic diet, abundant liquid and solid cholesterol crystals that precede formation of macroscopic cholesterol gallstones are observed after 9 days

abnormal bile canaliculus morphology ( J:115285 )

• in mutant livers, bile canaliculi show extensive branching at membrane surface

abnormal gallbladder physiology ( J:115285 )

• Background Sensitivity: occlusion of gall bladder with mucin occurs at 7 days on a lithogenic diet compared to 18 hours on the FVB/NJ background

abnormal bile composition ( J:115285 )

• Background Sensitivity: phospholipids in bile of mice on a chow diet are 1.3 fold higher than littermates

• Background Sensitivity: on a lithogenic diet, after 7 days, mice have 1.3 fold lower phospholipid levels in bile

• Background Sensitivity: on a lithogenic diet, after 7 days, mice have 1.3 fold lower biliary cholesterol levels in bile compared to wild-type littermates

homeostasis/metabolism

abnormal bile salt level ( J:115285 )

• on a lithogenic diet, TUDC concentration increases in mutants and controls, but remain higher in mutants; TC remains unchanged in mutants but increases in wild-type

• Background Sensitivity: relative concentration of tauromuricholate (TMC) is reduced and tauroursdeoxycholate (TUDC) and taurocholate (TC) concentrations are increased compared to control

• Background Sensitivity: bile salt concentrations are 1.3 fold lower than controls on lithogenic diets compared to mutants on the FVB/NJ background

abnormal phospholipid level ( J:115285 )

• phospholipids in bile of mice on a chow diet are 1.3 fold higher than littermates

• on a lithogenic diet, after 7 days, mice have 1.3 fold lower phospholipid levels in bile