Phenotypes Associated with This Genotype

Genotype
MGI:3695292

• Allelic Composition: Pctp^tm1Bor/Pctp^tm1Bor
• Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal bile canaliculus morphology ( J:115285 )

• in mutant livers, bile canaliculi show extensive branching at membrane surface

• bile canaliculi and junctional complexes appear more tortuous

abnormal gallbladder physiology ( J:115285 )

• Background Sensitivity: occlusion of gall bladder with mucin occurs at 18 hours on a lithogenic diet

• Background Sensitivity: occlusion occurs much more quickly than on the C57BL/6J background

abnormal bile secretion ( J:115285 )

• bile flow rate is reduced by ~35% after 30 minutes in mutants on a regular chow diet

homeostasis/metabolism

abnormal bile salt level ( J:115285 )

• Background Sensitivity: bile salt concentrations are 4.3 fold higher than controls on regular chow diets

• Background Sensitivity: there is marked increase in bile salt secretion on chow diet

• Background Sensitivity: on lithogenic diet, concentration decreases; in wild-type, concentrations increase such that both genotypes have similar bile salt concentrations

• Background Sensitivity: on a chow diet, TC concentration is higher than controls, while other bile salt concentrations are reduced; on a lithogenic diet, percentage of TUDC is higher in mutants, but other types are similar in both mutants and controls

decreased cholesterol level ( J:115285 )

• Background Sensitivity: on a lithogenic diet, biliary cholesterol levels decrease, but levels increase in wild-type

increased cholesterol level ( J:115285 )

• Background Sensitivity: in chow-fed mice, biliary cholesterol levels are 5.9 fold higher than in controls