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Phenotypes Associated with This Genotype
Genotype
MGI:3695293
Allelic
Composition		 Pctptm1Bor/Pctptm1Bor
Genetic
Background		 B6.129P2-Pctptm1Bor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pctptm1Bor mutation (1 available); any Pctp mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:115284 )
• macrophages loaded with cholesteryl esters show impaired apoAI-mediated efflux of phospholipids and cholesterol compared to wild-type macrophages
increased macrophage apoptosis ( J:115284 )
• macrophages loaded with free (unesterified) cholesterol (FC) show significantly more apoptotic cell death and total cell death compared to FC-loaded wild-type macrophages

cellular
increased macrophage apoptosis ( J:115284 )
• macrophages loaded with free (unesterified) cholesterol (FC) show significantly more apoptotic cell death and total cell death compared to FC-loaded wild-type macrophages

hematopoietic system
abnormal macrophage physiology ( J:115284 )
• macrophages loaded with cholesteryl esters show impaired apoAI-mediated efflux of phospholipids and cholesterol compared to wild-type macrophages
increased macrophage apoptosis ( J:115284 )
• macrophages loaded with free (unesterified) cholesterol (FC) show significantly more apoptotic cell death and total cell death compared to FC-loaded wild-type macrophages

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory