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Phenotypes Associated with This Genotype
Genotype
MGI:3695386
Allelic
Composition		 Lat2tm1Wz/Lat2tm1Wz
Genetic
Background		 B6.Cg-Lat2tm1Wz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat2tm1Wz mutation (0 available); any Lat2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
spleen hyperplasia ( J:116157 )
• enlarged in mice older than 6 months of age but not in mice at 5 - 8 weeks of age
• total number of splenocytes is increased to (9.5 +/- 2.0) x 107 compared to (4.4 +/- 0.6) x 107 in wild-type mice
abnormal T cell physiology ( J:116157 )
• increased expression of CD25, CD69, and CD44 and decreased expression of CD62L and CD45RB
increased T cell proliferation ( J:116157 )
• increased in the presence of low concentrations of anti-CD3 (0.05 mg/ul) compared to wild-type mice
abnormal CD8-positive, alpha-beta T cell physiology ( J:116157 )
• isolated cells produce more IL-2, IL-10, TNFA, and IFNG after stimulation with PMA and ionomycin
abnormal cytokine secretion ( J:116157 )
• splenocytes stimulated with PMA and ionomycin produce more IL-2, IL10, and IFNG
increased autoantibody level ( J:116157 )
• elevated at 6 months of age and even more so at 1 year
increased anti-double stranded DNA antibody level ( J:116157 )
• high titers of dsDNA antibodies are found at 6 months of age

hematopoietic system
spleen hyperplasia ( J:116157 )
• enlarged in mice older than 6 months of age but not in mice at 5 - 8 weeks of age
• total number of splenocytes is increased to (9.5 +/- 2.0) x 107 compared to (4.4 +/- 0.6) x 107 in wild-type mice
abnormal T cell physiology ( J:116157 )
• increased expression of CD25, CD69, and CD44 and decreased expression of CD62L and CD45RB
increased T cell proliferation ( J:116157 )
• increased in the presence of low concentrations of anti-CD3 (0.05 mg/ul) compared to wild-type mice
abnormal CD8-positive, alpha-beta T cell physiology ( J:116157 )
• isolated cells produce more IL-2, IL-10, TNFA, and IFNG after stimulation with PMA and ionomycin

cellular
increased T cell proliferation ( J:116157 )
• increased in the presence of low concentrations of anti-CD3 (0.05 mg/ul) compared to wild-type mice

growth/size/body
spleen hyperplasia ( J:116157 )
• enlarged in mice older than 6 months of age but not in mice at 5 - 8 weeks of age
• total number of splenocytes is increased to (9.5 +/- 2.0) x 107 compared to (4.4 +/- 0.6) x 107 in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory