Phenotypes Associated with This Genotype

Genotype
MGI:3695390

• Allelic Composition: Lat2^tm2Wz/Lat2^tm2Wz; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:116157 )

• at 6 months of age

increased activated T cell number ( J:116157 )

• increased number of activated CD4 cells at 6 months of age

abnormal CD4-positive, alpha-beta T cell physiology ( J:116157 )

• increased production of IL-2, IL-10, and IFNG

increased anti-double stranded DNA antibody level ( J:116157 )

• high titers of dsDNA antibodies are present at 6 months of age

hematopoietic system

enlarged spleen ( J:116157 )

• at 6 months of age

increased activated T cell number ( J:116157 )

• increased number of activated CD4 cells at 6 months of age

abnormal CD4-positive, alpha-beta T cell physiology ( J:116157 )

• increased production of IL-2, IL-10, and IFNG

growth/size/body

enlarged spleen ( J:116157 )

• at 6 months of age