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Phenotypes Associated with This Genotype
Genotype
MGI:3696112
Allelic
Composition		 Casp1tm1Sesh/Casp1+
Casp4del/Casp4+
Genetic
Background		 involves: 129S1/SvImJ * 129S2/SvPas * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Sesh mutation (5 available); any Casp1 mutation (42 available)
Casp4del mutation (5 available); any Casp4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:99748 )
• Casp1-deficient bone marrow-derived macrophages that are homozygous for the 129S1 Nlrp1b transgene are highly resistant to necrosis induced by B. antracis lethal toxin (LeTx) while Casp1-heterozygous mice that are homozygous for the 129S1 Nlrp1b allele show a high susceptibility to necrosis from LeTx

hematopoietic system
abnormal macrophage physiology ( J:99748 )
• Casp1-deficient bone marrow-derived macrophages that are homozygous for the 129S1 Nlrp1b transgene are highly resistant to necrosis induced by B. antracis lethal toxin (LeTx) while Casp1-heterozygous mice that are homozygous for the 129S1 Nlrp1b allele show a high susceptibility to necrosis from LeTx

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory