Phenotypes Associated with This Genotype

Genotype
MGI:3697242

• Allelic Composition: Apoc1^tm1Lmh/Apoc1^tm1Lmh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid level ( J:117482 )

• hepatic levels are markedly increased (by 31.4%) compared to controls as result of 57.8% increase in cholesteryl ester content

abnormal circulating cholesterol level ( J:22858 )

• total circulating cholesterol level is normal, but relative amount in VLDL + LDL-sized fraction is doubled compared to wild-type mice on HFC diet

increased circulating triglyceride level ( J:22858 )

• total serum triacylglycerols are slightly increased compared to controls; this increase is confined to the VLDL + LDL -sized fractions

• after 3 weeks on a mild high-fat/cholesterol diet (HFC), serum levels are elevated 1.6 fold

increased cholesterol level ( J:117482 )

• biliary cholester concentration is higher than in wild-type

increased circulating cholesterol level ( J:22858 )

• when fed a severe high-fat/cholesterol diet (HFC0.5% - contains 1% cholesterol, 0.5% cholate), serum levels are increased to 10.7 mM compared to 6.7 and 5.1 mM in heterozygous and wild-type controls

increased liver triglyceride level ( J:117482 )

• 118.4% increased in hepatic triglyceride levels vs controls

liver/biliary system

increased liver triglyceride level ( J:117482 )

• 118.4% increased in hepatic triglyceride levels vs controls

abnormal bile composition ( J:117482 )

• biliary cholester concentration is higher than in wild-type; cholesterol to bile salt ratio is 37.8% higher than in controls