Phenotypes Associated with This Genotype

Genotype
MGI:3697301

• Allelic Composition: Apoc1^tm1Lmh/Apoc1^tm1Lmh; Tg(CETP)5203Tall/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid level ( J:117482 )

• hepatic level increase is attenuated by transgene expression (by 58.2%) compared to controls

• hepatic cholesteryl ester levels are significantly higher than in wild-type or Tg(CETP)5203Tall controls

increased bile salt level ( J:117482 )

• bile acid level is increased by 19.6% compared to wild-type, Apoc1-deficient, or Tg(CETP)5303Tall mice

increased cholesterol level ( J:117482 )

• biliary cholesterol levels are increased by 87.7% compared to Tg(CETP)5203Tall mice; bile cholesterol is increased compared to Apoc1-deficient or Tg(CETP)5203Tall mice

abnormal phospholipid level ( J:117482 )

• levels are increased compared to wild-type or Tg(CETP)5203Tall mice

increased liver triglyceride level ( J:117482 )

• 302.4% increased in hepatic triglyceride levels vs wild-type or Tg(CETP)5303Tall controls

liver/biliary system

increased liver triglyceride level ( J:117482 )

• 302.4% increased in hepatic triglyceride levels vs wild-type or Tg(CETP)5303Tall controls

abnormal bile composition ( J:117482 )

• all lipids in bile are increased in concentration compared to wild-type levels; cholesterol to bile salt ratio is increased by 54.3% and phospholipids to bile salt ratio is increased 48.1% compared to Tg(CETP)5303Tall mice