Phenotypes Associated with This Genotype

Genotype
MGI:3697329

• Allelic Composition: Apoc1^tm2Lmh/Apoc1^tm2Lmh; Apoe^tm1Bres/Apoe^tm1Bres
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:28261 )

• in controls, main cholesterol carrier is HDL and only ~10% is contained in the VLDL/LDL-sized fraction, while in mutants, most of the cholesterol (71%) is found in VLDL/LDL-sized fractions

increased circulating cholesterol level ( J:28261 )

• on a normal chow diet, mice are severely hypercholesterolemic compared to controls (12.5 mM vs 2.9 mM in controls)

• on mild high-fat/cholesterol (HFC) diet with 15% fat/0.25% cholesterol, serum cholesterol is increased 8-fold (to 31mM from 3.8 mM) with most of the increase found in VLDL/LDL-sized fractions