Phenotypes Associated with This Genotype

Genotype
MGI:3697437

• Allelic Composition: Efnb2^tm1.1Henk/Efnb2^tm1.1Henk
• Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:91492 )

• at E9 and E10, all homozygotes are visibly abnormal and necrotic

• no viable homozygotes are obtained after E10

cardiovascular system

abnormal blood vessel morphology ( J:91492 )

• at E9, homozygotes exhibit abnormal vascular structures

abnormal cardiovascular development ( J:91492 )

• at E9 and E10, homozygotes display failure of cardiovascular development

abnormal angiogenesis ( J:91492 )

• at E9, homozygotes display disrupted angiogenic remodeling

abnormal vitelline vasculature morphology ( J:91492 )

• at E9, homozygotes show obvious defects in extraembryonic (yolk sac) blood vessels

abnormal heart morphology ( J:91492 )

• at E9, homozygotes exhibit abnormal heart structures

enlarged pericardium ( J:91492 )

• at E9 and E10, homozygotes display enlarged pericardia

embryo

abnormal vitelline vasculature morphology ( J:91492 )

• at E9, homozygotes show obvious defects in extraembryonic (yolk sac) blood vessels

embryonic growth retardation ( J:91492 )

• at E9, homozygotes appear to be growth-retarded

decreased embryo size ( J:91492 )

• at E9 and E10, homozygotes are smaller than wild-type embryos

abnormal vitelline vascular remodeling ( J:91492 )

• at E9, homozygotes display remodeling defects in the blood vessels within the yolk sacs

growth/size/body

embryonic growth retardation ( J:91492 )

• at E9, homozygotes appear to be growth-retarded

decreased embryo size ( J:91492 )

• at E9 and E10, homozygotes are smaller than wild-type embryos