Phenotypes Associated with This Genotype

Genotype
MGI:3697461

• Allelic Composition: Gata3^tm3Gsv/Gata3^tm3Gsv; Tg(KRT14-cre)8Brn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

absent nipple ( J:117058 )

♀ • absence of visible nipples

enlarged sebaceous gland ( J:117058 )

• from P7 onwards

growth/size/body

decreased body size ( J:117058 )

weight loss ( J:117058 )

• during the first month of life

postnatal growth retardation ( J:117058 )

• apparent from P2 onwards

adipose tissue

absent subcutaneous adipose tissue ( J:117058 )

• reduced amount of subcutaneous adipose tissue

vision/eye

narrow eye opening ( J:117058 )

• eyes appear half-opened throughout life

hematopoietic system

decreased T cell number ( J:117058 )

• decrease in the number of CD3+ T cells and MHC class II cells in the skin

immune system

decreased T cell number ( J:117058 )

• decrease in the number of CD3+ T cells and MHC class II cells in the skin

homeostasis/metabolism

impaired skin barrier function ( J:117058 )

• slight delay in the development of skin barrier function at E16.5, E17.5, and E18.5

pigmentation

abnormal hair follicle melanin granule morphology ( J:117058 )

• pigment deposition is irregular and lacks the air spaces seen in wild-type hair

integument

absent subcutaneous adipose tissue ( J:117058 )

• reduced amount of subcutaneous adipose tissue

absent nipple ( J:117058 )

♀ • absence of visible nipples

enlarged sebaceous gland ( J:117058 )

• from P7 onwards

impaired skin barrier function ( J:117058 )

• slight delay in the development of skin barrier function at E16.5, E17.5, and E18.5

abnormal hair growth ( J:117058 )

delayed hair appearance ( J:117058 )

• mice remain bald at P10

progressive hair loss ( J:117058 )

• gradual loss of abdominal hair

• anterior to posterior shedding in the head area with limited hair regeneration

short hair ( J:117058 )

• hair that does grow is short and stubby

sparse hair ( J:117058 )

• sparse hair growth around the head and neck starting from P12

abnormal hair texture ( J:117058 )

• remaining hairs are irregular with a short, thick, and hard appearance and a rounded tip

abnormal hair follicle morphology ( J:117058 )

• in some follicles small cysts develop by 5 months of age

• increase in the number of cells expressing stem cell markers in distal hair follicles

• the hair follicle and epidermal stem cell marker expression domains are connected rather than separate as in wild-type mice

• expanded precortex and cortex

• a decrease in the number of proliferating cells close to the hair bulb

abnormal hair follicle melanin granule morphology ( J:117058 )

• pigment deposition is irregular and lacks the air spaces seen in wild-type hair

abnormal hair follicle inner root sheath morphology ( J:117058 )

• absence of the companion layer that normally separates AE15+ and K14+ cells in inner root sheath cells

• absence of Huxley's layer and cuticle of the inner root sheath

abnormal hair follicle orientation ( J:117058 )

• grow at a wider angle, often parallel to the skin surface

• however, the overall hair follicle number is not reduced

abnormal hair follicle outer root sheath morphology ( J:117058 )

• increase in the number of proliferating cells in the outer root sheath

thick hair follicle outer root sheath ( J:117058 )

• the outer root sheath is about twice as thick as in wild-type mice

short vibrissae ( J:117058 )

• short and thick

abnormal hair cycle ( J:117058 )

• catagen is prolonged lasting for 6 days after which hair follicles enter telogen where in most cases the proximal end of the follicle fails to reform

abnormal skin morphology ( J:117058 )

• decrease in the number of apoptotic cells

thin dermal layer ( J:117058 )

abnormal epidermal layer morphology ( J:117058 )

• increase in the number of cells expressing stem cell markers

• the hair follicle and epidermal stem cell marker expression domains are connected rather than separate as in wild-type mice

abnormal epidermis stratum basale morphology ( J:117058 )

• increase in the number of proliferating cells at P7 and P11-15

hyperkeratosis ( J:117058 )

epidermal hyperplasia ( J:117058 )

• pronounced hyperplasia beginning at P3

thick epidermis ( J:117058 )

• gradual, pronounce epidermal thickening that involves the basal and suprabasal layers

• the basal epidermal layer is about twice as thick as in wild-type

scaly skin ( J:117058 )

• squames cover the skin wrinkles

wrinkled skin ( J:117058 )

• develops after onset of epidermal hyperplasia

abnormal skin condition ( J:117058 )