endocrine/exocrine glands
|
• absence of visible nipples
|
• from P7 onwards
|
growth/size/body
weight loss
(
J:117058
)
• during the first month of life
|
• apparent from P2 onwards
|
adipose tissue
• reduced amount of subcutaneous adipose tissue
|
vision/eye
• eyes appear half-opened throughout life
|
hematopoietic system
• decrease in the number of CD3+ T cells and MHC class II cells in the skin
|
immune system
• decrease in the number of CD3+ T cells and MHC class II cells in the skin
|
homeostasis/metabolism
• slight delay in the development of skin barrier function at E16.5, E17.5, and E18.5
|
pigmentation
• pigment deposition is irregular and lacks the air spaces seen in wild-type hair
|
integument
• reduced amount of subcutaneous adipose tissue
|
|
• absence of visible nipples
|
• from P7 onwards
|
• slight delay in the development of skin barrier function at E16.5, E17.5, and E18.5
|
• mice remain bald at P10
|
• gradual loss of abdominal hair
• anterior to posterior shedding in the head area with limited hair regeneration
|
short hair
(
J:117058
)
• hair that does grow is short and stubby
|
sparse hair
(
J:117058
)
• sparse hair growth around the head and neck starting from P12
|
• remaining hairs are irregular with a short, thick, and hard appearance and a rounded tip
|
• in some follicles small cysts develop by 5 months of age
• increase in the number of cells expressing stem cell markers in distal hair follicles
• the hair follicle and epidermal stem cell marker expression domains are connected rather than separate as in wild-type mice
• expanded precortex and cortex
• a decrease in the number of proliferating cells close to the hair bulb
|
• pigment deposition is irregular and lacks the air spaces seen in wild-type hair
|
• absence of the companion layer that normally separates AE15+ and K14+ cells in inner root sheath cells
• absence of Huxley's layer and cuticle of the inner root sheath
|
• grow at a wider angle, often parallel to the skin surface
• however, the overall hair follicle number is not reduced
|
• increase in the number of proliferating cells in the outer root sheath
|
• the outer root sheath is about twice as thick as in wild-type mice
|
• short and thick
|
• catagen is prolonged lasting for 6 days after which hair follicles enter telogen where in most cases the proximal end of the follicle fails to reform
|
• decrease in the number of apoptotic cells
|
• increase in the number of cells expressing stem cell markers
• the hair follicle and epidermal stem cell marker expression domains are connected rather than separate as in wild-type mice
|
• increase in the number of proliferating cells at P7 and P11-15
|
• pronounced hyperplasia beginning at P3
|
• gradual, pronounce epidermal thickening that involves the basal and suprabasal layers
• the basal epidermal layer is about twice as thick as in wild-type
|
scaly skin
(
J:117058
)
• squames cover the skin wrinkles
|
• develops after onset of epidermal hyperplasia
|