Phenotypes for Dkk1 Sfrp5 MGI:3697480 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dkk1^tm1Lmgd/Dkk1^tm1Lmgd Sfrp5^tm1Shwl/Sfrp5^tm1Shwl
Genetic Background	involves: 129 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1^tm1Lmgd mutation (0 available); any Dkk1 mutation (19 available)
Sfrp5^tm1Shwl mutation (0 available); any Sfrp5 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:117057 )

• no viable double homozygotes are found

embryo

embryo phenotype ( J:117057 )

N	• location of the anterior visceral endoderm and primitive streak morphology are similar to controls

growth/size/body

abnormal anterior head development ( J:117057 )

• at E17.5 9 of 18 mice lack anterior head structures

• this is not significantly different from Dkk1 single homozygotes on the same genetic background

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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