Phenotypes Associated with This Genotype

Genotype
MGI:3698526

• Allelic Composition: Ctsk^tm1Ypl/Ctsk^tm1Ypl
• Genetic Background: B6.129S4-Ctsk^tm1Ypl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:117870 )

N • Background Sensitivity: on a C57BL/6J background, mutants do not exhibit a lower weight as is seen on a 129S4 background

skeleton

abnormal skeleton morphology ( J:117870 )

• Background Sensitivity: on the C57BL/6J background, exhibit fewer of the traits associated with pycnodysostosis than on a 129S4 background, and do not show acroosteolysis or spondylolysis of the distal phalanges

increased osteoclast cell number ( J:117870 )

• Background Sensitivity: display about a 2-fold increase in osteoclast numbers, a much lower increase than seen on a 129S4 background

osteopetrosis ( J:117870 )

• Background Sensitivity: exhibit only mild osteopetrosis on the C57BL/6J background unlike on a 129S4 background

hematopoietic system

increased osteoclast cell number ( J:117870 )

• Background Sensitivity: display about a 2-fold increase in osteoclast numbers, a much lower increase than seen on a 129S4 background

immune system

increased osteoclast cell number ( J:117870 )

• Background Sensitivity: display about a 2-fold increase in osteoclast numbers, a much lower increase than seen on a 129S4 background