Analysis Tools
cardiovascular system
 |
• when subjected to 15% to 20% stretch, cardiac muscles exhibit reduced diastolic stress compared to wild-type muscle
• when stretched to a diastolic stress of 20 kPA, sarcomere length in cardiac muscles is increased compared to in wild-type muscle
• however, other active mechanical properties such as developed systolic stress, time to peak contraction, maximum rate of force production, 90% relaxation time, and maximum rate of force decline are normal
|
|
|
• cardiac hypertrophy following transverse aortic constriction (TAC) is less than in wild-type mice with smaller left ventricular to body weight ratio, cardiomyocyte cross-sectional area, left ventricle posterior wall thickness, and interventricular septal wall thickness
• the percentage of left ventricle fractional shortening following TAC is similar to in sham-operated mice
• cardiac function following TAC is preserved unlike in similarly treated wild-type mice
|
homeostasis/metabolism
|
|
• cardiac hypertrophy following transverse aortic constriction (TAC) is less than in wild-type mice with smaller left ventricular to body weight ratio, cardiomyocyte cross-sectional area, left ventricle posterior wall thickness, and interventricular septal wall thickness
• the percentage of left ventricle fractional shortening following TAC is similar to in sham-operated mice
• cardiac function following TAC is preserved unlike in similarly treated wild-type mice
|
behavior/neurological
|
N |
• gross behavior is normal
|
nervous system
|
N |
• males exhibit normal brain weight and morphology
|
growth/size/body
|
N |
• body weight is normal
|
