Phenotypes Associated with This Genotype

Genotype
MGI:3698746

• Allelic Composition: Apoa4^tm1Bres/Apoa4^tm1Bres
• Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:43015 )

• decreased triglyceride transport rate

decreased circulating triglyceride level ( J:43015 )

• reduced 45%

• levels are tied more to Apoa3 levels (which are also reduced) than to Apoa4 levels

decreased circulating VLDL triglyceride level ( J:43015 )

• reduced 61%

abnormal cholesterol homeostasis ( J:43015 )

• 27% increase in the HDL-cholesterol ester catabolic rate

decreased circulating cholesterol level ( J:43015 )

• reduced 23% in both fed and fasted state

decreased circulating HDL cholesterol level ( J:43015 )

• reduced 23%

behavior/neurological

increased food intake ( J:43015 )

• animals fasted 18 hours before being given unlimited food had higher short term food intake than controls but the difference is only significant on a predominantly 129 background