Phenotypes Associated with This Genotype

Genotype
MGI:3699806

• Allelic Composition: Cxcl14^tm1Bmsr/Cxcl14^tm1Bmsr
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:118303 )

• at screening, only 10.6% of mice are homozygous, in contrast to expected 25%; no time point when lethality occurs is indicated

growth/size/body

decreased body weight ( J:118303 )

immune system

immune system phenotype ( J:118303 )

N • normal distribution of leukocyte populations in blood and lymphoid tissues is observed; macrophages and dendritic cells are present in normal numbers in epithelial tissues and Langerhans cells display normal activation and skin emigration properties

N • normal skin dendritic cell function in response to inflammation, normal peritoneal recruitment of inflammatory macrophages, and unchanged skin wound healing are seen in mutants

reproductive system

decreased litter size ( J:118303 )

• litter size produced by homozygous pairs appear smaller than normal, with some pups dying between days 2 and 3 after birth