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Phenotypes Associated with This Genotype
Genotype
MGI:3699821
Allelic
Composition		 Aifm1Hq/Aifm1Hq
Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aifm1Hq mutation (2 available); any Aifm1 mutation (11 available)
Apaf1Gt(IRESBetageo)XIX18Pgr mutation (0 available); any Apaf1 mutation (77 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neuron apoptosis ( J:98103 )
• reduced apoptosis of cultured cortical neurons resulting from treatment with camptothecin
• neurons show enhanced viability when treated with camptothecin
• only about half of dying cells exhibit DNA fragmentation

cellular
decreased neuron apoptosis ( J:98103 )
• reduced apoptosis of cultured cortical neurons resulting from treatment with camptothecin
• neurons show enhanced viability when treated with camptothecin
• only about half of dying cells exhibit DNA fragmentation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory