Phenotypes for Mdm2 Mdm4 Trp53 MGI:3700144 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mdm2^tm1Glo/Mdm2⁺ Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm3Wahl/Trp53^tm3Wahl
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (193 available)
Trp53^tm3Wahl mutation (0 available); any Trp53 mutation (244 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:108183 )

• cell cycle arrest in irradiate MEFs is improved compared to Trp53 single homozygous MEFs but is still not as robust as in wild-type MEFs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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