Phenotypes Associated with This Genotype

Genotype
MGI:3700742

• Allelic Composition: Kcne2^tm1Gwab/Kcne2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:116518 )

N • parietal and chief cell morphology appears similar to wild-type controls despite the decrease in stomach pH

decreased digestive secretion ( J:116518 )

• acid loaded parietal cells have a lower rate of proton secretion, about 0.05 pH units/minute compared to about 0.1 units/minute in wild-type controls

hypochlorhydria ( J:116518 )

• mice display hypochlohydria

increased stomach pH ( J:116518 )

• mean luminal pH in the stomach under basal conditions is 4.6 +/- 0.2 compared to 3.9 +/- 0.1 in wild-type controls

• however, luminal pH is significantly altered by histamine similar to wild-type controls and unlike homozygous mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:116518 )

N • serum gastrin levels are similar to wild-type controls