Phenotypes Associated with This Genotype

Genotype
MGI:3700923

• Allelic Composition: Syne1^tm1Rexu/Syne1^tm1Rexu
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle fiber morphology ( J:118671 )

• nuclei are disorganized in muscle fibers of mutants; nuclei cluster abnormally, with >99% of muscle fibers have nuclear clusters

• numbers of synaptic nuclei is reduced, but numbers of nuclei peripheral to synapse are increased compared to controls

nervous system

abnormal neuromuscular synapse morphology ( J:118671 )

• no nuclei are observed under the neuromuscular junctions (NMJ) in mutants, compared to 4-5 seen in controls; synapse-associated nuclei are dramatically reduced in number compared to controls