Phenotypes Associated with This Genotype

Genotype
MGI:3700925

• Allelic Composition: Syne1^tm1Rexu/Syne1^tm1Rexu; Syne2^tm1Rexu/Syne2^tm1Rexu
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:118671 )

• double homozygotes are born, but die within 20 minutes

respiratory system

abnormal respiratory mechanics ( J:118671 )

• mice fail to move their ribcages, but can move limbs in response to stimuli

respiratory failure ( J:118671 )

• mice are unable to breathe

nervous system

abnormal neuromuscular synapse morphology ( J:118671 )

• phrenic nerve-diaphragm neuromuscular synapses have broader endplates than controls

abnormal phrenic nerve morphology ( J:118671 )

• phrenic nerve has significantly longer branches than controls