Phenotypes Associated with This Genotype

Genotype
MGI:3702894

• Allelic Composition: Igkc^tm1Bgmn/Igkc^tm1Bgmn; Igl^tm1.1Bgmn/Igl^tm1.1Bgmn
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal immature B cell morphology ( J:118712 )

• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 10⁶) in bone marrow is reduced by >50% compared to Igk-C^tm1Bgmn mice

decreased B cell number ( J:118712 )

• IgM+ B cells are reduced in number in spleen and secondary lymph organs

absent B-1 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-1 cells

absent B-2 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-2 cells

absent B cells ( J:118712 )

• there is complete lack of mature B cells in spleen

spleen hypoplasia ( J:118712 )

• total cell numbers and weights are reduced by more than half compared to wild-type

immune system

abnormal immature B cell morphology ( J:118712 )

• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 10⁶) in bone marrow is reduced by >50% compared to Igk-C^tm1Bgmn mice

decreased B cell number ( J:118712 )

• IgM+ B cells are reduced in number in spleen and secondary lymph organs

absent B-1 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-1 cells

absent B-2 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-2 cells

absent B cells ( J:118712 )

• there is complete lack of mature B cells in spleen

spleen hypoplasia ( J:118712 )

• total cell numbers and weights are reduced by more than half compared to wild-type