Phenotypes Associated with This Genotype

Genotype
MGI:3702949

• Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺; Procr^tm2Cte/Procr^tm2Cte
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal hematopoietic system morphology/development ( J:119529 )

• mutants have slightly increased thrombin-antithrombin (TAT) complex levels

thrombocytopenia ( J:119529 )

• 2-month old mice show decreased platelet counts compared to wild-type; differences increase and become significant with age

homeostasis/metabolism

increased circulating C-reactive protein level ( J:119529 )

• circulating levels are higher in 2 month old mutants

• however, after thrombin infusion, circulating APC (activated protein C) levels are only 5.2% that of wild-type controls

decreased circulating fibrinogen level ( J:119529 )

• fibrinogen levels are decreased relative to wild-type; differences increase and become significant with age

immune system

increased circulating C-reactive protein level ( J:119529 )

• circulating levels are higher in 2 month old mutants

• however, after thrombin infusion, circulating APC (activated protein C) levels are only 5.2% that of wild-type controls

decreased circulating fibrinogen level ( J:119529 )

• fibrinogen levels are decreased relative to wild-type; differences increase and become significant with age