Phenotypes Associated with This Genotype

Genotype
MGI:3702968

• Allelic Composition: Gdf5^bp-J/Gdf5^bp-J
• Genetic Background: A/J-Gdf5^bp-J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal limb mesenchyme morphology ( J:17582 )

• mesenchyme from mutant mice shows a reduced ability to form aggregates and cartilaginous nodules in vitro

limbs/digits/tail

brachypodia ( J:17582 )

• feet are much shorter than controls

abnormal digit morphology ( J:17582 )

• the reduction in length of the feet is largely the result of altered patterning of segments in the digits

abnormal limb bone morphology ( J:59288 )

• mice have unusual sesamoid morphology

abnormal carpal bone morphology ( J:17582 )

• slight disorganization of the carpals and tarsals

abnormal phalanx morphology ( J:59288 )

• P1 and P2 are replaced by a single rudimentary element (P1/P2)

brachyphalangia ( J:59282 )

• the proximal and middle phalanges are reduced

fused phalanges ( J:17582 , J:59282 )

• in place of the proximal and medial phalanges is a single bone resulting from a fusion of the proximal and medial phalangeal condensations (J:17582)

• the proximal and middle phalanges are fused (J:59282)

abnormal tarsal bone morphology ( J:17582 )

• slight disorganization of the carpals and tarsals

short metacarpal bones ( J:17582 , J:59282 )

• defects in the length of the metacarpals (J:17582)

short metatarsal bones ( J:17582 , J:59282 )

• defects in the length of the metatarsals (J:17582)

abnormal limb development ( J:59288 )

• in mutants, length of long bones of forelimbs and hindlimbs is severely reduced

abnormal limb mesenchyme morphology ( J:17582 )

• mesenchyme from mutant mice shows a reduced ability to form aggregates and cartilaginous nodules in vitro

abnormal digit development ( J:17582 )

• digit condensations in mutant mice are thin, malformed, and slow to initiate chondrogenesis

skeleton

abnormal limb bone morphology ( J:59288 )

• mice have unusual sesamoid morphology

abnormal carpal bone morphology ( J:17582 )

• slight disorganization of the carpals and tarsals

abnormal phalanx morphology ( J:59288 )

• P1 and P2 are replaced by a single rudimentary element (P1/P2)

brachyphalangia ( J:59282 )

• the proximal and middle phalanges are reduced

fused phalanges ( J:17582 , J:59282 )

• in place of the proximal and medial phalanges is a single bone resulting from a fusion of the proximal and medial phalangeal condensations (J:17582)

• the proximal and middle phalanges are fused (J:59282)

abnormal tarsal bone morphology ( J:17582 )

• slight disorganization of the carpals and tarsals

decreased length of long bones ( J:17582 )

• long bones of the limb are slightly shorter

short metacarpal bones ( J:17582 , J:59282 )

• defects in the length of the metacarpals (J:17582)

short metatarsal bones ( J:17582 , J:59282 )

• defects in the length of the metatarsals (J:17582)

joint dislocation ( J:59282 )

• mutants exhibit frequent joint dislocations