Phenotypes Associated with This Genotype

Genotype
MGI:3703752

• Allelic Composition: Tg(H2-K-AKR1B1)1Tj/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

cataract ( J:120049 )

• 7/15 transgenic mice developed cataracts when fed a 20% galactose diet for 7 days; 2/7 only displayed cataracts while 5 mice also developed occlusion of the retinochoroidal vessels

renal/urinary system

abnormal renal glomerular capsule morphology ( J:120049 )

• multiple fibrinous deposits were observed in the Bowman's capsule of many glomeruli in 4/5 mice fed a normal diet

• mice fed a 20% galactose diet show fibrinous deposits in Bowman's capsules of kidneys while littermates fed the same diet show no histopathological changes

cardiovascular system

abnormal blood vessel morphology ( J:120049 )

• 5/15 mice fed a 20% galactose diet for 7 days developed cataracts and occlusion of retinochoroidal vessels while another 2 mice developed vascular occlusion only

homeostasis/metabolism

abnormal glucose homeostasis ( J:120049 )

• sorbitol concentration in liver, kidney, and muscle after intake of 30% glucose chow for 5 days increases by 1.7, 2.1, and 2.0, respectively compared to control littermates; levels with normal diet are not significantly different between transgenic mice and controls

abnormal enzyme/coenzyme activity ( J:120049 )

• activity of purified AR from transgenic mouse muscle is 5-6 fold higher than in muscle from littermates