Phenotypes Associated with This Genotype

Genotype
MGI:3706133

• Allelic Composition: Rictor^tm1.2Mgn/Rictor^tm1.3Mgn
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119564 )

• expected Mendelian distribution ratios by E9.5 and indistinguishable from either wild-type or heterozygous littermates

• showed growth arrest beginning between E9.5 and E10.5

• live embryos were not observed at E11.5

embryo

decreased embryo size ( J:119564 )

• at E10.5

abnormal placenta labyrinth morphology ( J:119564 )

• labyrinth layer remains cell dense in most E10.5 mutant placentas

abnormal placental labyrinth vasculature morphology ( J:119564 )

• exhibit fewer maternal-fetal interfaces in most E10.5 mutant placentas

growth/size/body

decreased embryo size ( J:119564 )

• at E10.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:119564 )

• exhibit fewer maternal-fetal interfaces in most E10.5 mutant placentas