Phenotypes Associated with This Genotype

Genotype
MGI:3706173

• Allelic Composition: Btla^tm1Kmm/Btla^tm1Kmm; Pdcd1^tm1Hon/Pdcd1^tm1Hon
• Genetic Background: B6.129S-Pdcd1^tm1Hon Btla^tm1Kmm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:119356 )

• increase in proliferation in response to fully MHC-mismatched stimulation

• increase is decreased by rapamycin treatment

decreased length of allograft survival ( J:119356 )

• decreased survival time of cardiac allografts (source strain Bm12; 10.5 +/- 1.5 days) compared to mice homozygous for the Btla allele alone (14.3 +/- 3.8 days) or wild-type mice (over 100 days)

hematopoietic system

increased T cell proliferation ( J:119356 )

• increase in proliferation in response to fully MHC-mismatched stimulation

• increase is decreased by rapamycin treatment

cellular

increased T cell proliferation ( J:119356 )

• increase in proliferation in response to fully MHC-mismatched stimulation

• increase is decreased by rapamycin treatment