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Phenotypes Associated with This Genotype
Genotype
MGI:3706311
Allelic
Composition		 Erap1tm1Nsha/Erap1tm1Nsha
Tap1tm1Arp/Tap1tm1Arp
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erap1tm1Nsha mutation (0 available); any Erap1 mutation (59 available)
Tap1tm1Arp mutation (4 available); any Tap1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal antigen presentation via MHC class I ( J:116606 )
• BEko cells in wild-type mice are not activated by APCs (antigen expressing cells) from double mutants, compared to activation elicited by Arts1-single null APCs; response is similar to response of wild-type BEkos to Tap1-deficient APCs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory