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Phenotypes Associated with This Genotype
Genotype
MGI:3706899
Allelic
Composition		 Jak2tm1Kf/Jak2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1Kf mutation (0 available); any Jak2 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:112700 )
N
• hematocrit does not differ significantly from controls
• synthesis of new red blood cells following phenylhydrazine hydrolysis is not different from controls

homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:112700 )
• in isolated vascular aortic smooth muscle cells, levels of Jak2 autophophorylation are reduced compared to wild-type cells suggesting an inability to activate Jak2

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory