Phenotypes Associated with This Genotype

Genotype
MGI:3707238

• Allelic Composition: Tlr2^tm1Aki/Tlr2^tm1Aki; Tlr4^tm1Aki/Tlr4^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased IgG3 level ( J:117688 )

• significantly reduced in serum at 7 and 11 weeks of age

abnormal macrophage physiology ( J:117688 )

• in response to purified LPS, a Tlr4 agonist, or a Tlr2 agonist, macrophages do not produced TNFalpha or Il10, while production after stimulation by CpG, a Tlr9 agonist

• production of these cytokines is reduced upon stimulation with heat-killed gram negative bacteria, whereas response to gram-positive bacteria is comparable to wild-type

abnormal cytokine secretion ( J:117688 )

• TNFalpha and Il10 production is absent in response to Tlr2 or Tlr4 agonists, and is reduced in response to heat-killed gram negative bacteria

hematopoietic system

decreased IgG3 level ( J:117688 )

• significantly reduced in serum at 7 and 11 weeks of age

abnormal macrophage physiology ( J:117688 )

• in response to purified LPS, a Tlr4 agonist, or a Tlr2 agonist, macrophages do not produced TNFalpha or Il10, while production after stimulation by CpG, a Tlr9 agonist

• production of these cytokines is reduced upon stimulation with heat-killed gram negative bacteria, whereas response to gram-positive bacteria is comparable to wild-type