Phenotypes Associated with This Genotype

Genotype
MGI:3709891

• Allelic Composition: Tcf12^tm2Zhu/Tcf12^tm2Zhu; Tg(TcrAND)53Hed/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

arrested T cell differentiation ( J:120411 )

• block in T cell development is not rescued by transgene expression

abnormal T cell subpopulation ratio ( J:120411 )

• increased ratio of CD4 SP to DP cells is detected in thymus

increased T cell number ( J:120411 )

• no increase in the double positive T cell population or thymic cellularity relative to Tcf12^tm2Zhu homozygotes

• an increase in CD4 single positive cells is seen, indicating transgene expression can drive differentiation from the double positive (DP) to single positive (SP) stage

abnormal CD4-positive, alpha beta T cell morphology ( J:120411 )

• number of CD4 SP T cells is increased relative to nontransgenic Tcf12-null mice

• numbers of CD4 SP cells in thymus and peripheral lymphoid organs remains small relative to controls

hematopoietic system

arrested T cell differentiation ( J:120411 )

• block in T cell development is not rescued by transgene expression

abnormal T cell subpopulation ratio ( J:120411 )

• increased ratio of CD4 SP to DP cells is detected in thymus

increased T cell number ( J:120411 )

• no increase in the double positive T cell population or thymic cellularity relative to Tcf12^tm2Zhu homozygotes

• an increase in CD4 single positive cells is seen, indicating transgene expression can drive differentiation from the double positive (DP) to single positive (SP) stage

abnormal CD4-positive, alpha beta T cell morphology ( J:120411 )

• number of CD4 SP T cells is increased relative to nontransgenic Tcf12-null mice

• numbers of CD4 SP cells in thymus and peripheral lymphoid organs remains small relative to controls