Phenotypes Associated with This Genotype

Genotype
MGI:3710144

• Allelic Composition: Gnai1^tm1Drs/Gnai1^tm1Drs; Gnai3^tm1Lbi/Gnai3^tm1Lbi
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3

immune system

decreased interleukin-10 secretion ( J:104683 )

• decrease in IL-10 production from peritoneal monocytes after in vitro lipopolysaccharide-induction

increased tumor necrosis factor secretion ( J:104683 )

• increase in TNFa production from spleen monocytes after in vitro lipopolysaccharide-induction

homeostasis/metabolism

abnormal thromboxane level ( J:104683 )

• decreased thromboxane production B2 from peritoneal monocytes after in vitro lipopolysaccharide-induction

skeleton

sternebra fusion ( J:193170 )

asymmetric sternocostal joints ( J:193170 )

rib fusion ( J:193170 )

• rib fusions are more frequent and severe compared to mice homozygous for Gnai3^tm1Lbi alone

• rib fusions frequently involve both true and false ribs

lumbar vertebral fusion ( J:193170 )

• not noticeably more severe than in ice homozygous for Gnai3^tm1Lbi alone