Phenotypes Associated with This Genotype

Genotype
MGI:3710147

• Allelic Composition: Gnai3^tm1Lbi/Gnai3^tm1Lbi
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Fusion of lumbar vertebrae in Gnai3^tm1Lbi/Gnai3^tm1Lbi mice

skeleton

rib fusion ( J:193170 )

• Background Sensitivity: fusions of the cartilaginous portion of the distal ribs are seen in 95% of mice on a 129S/SvEv background but in less than 40% of mice on a mixed 129S/SvEv and C57BL/6 background

• Background Sensitivity: the average number of fusions is reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background

abnormal lumbar vertebrae morphology ( J:193170 )

• Background Sensitivity: incidence of lumbar defects in reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background

immune system

immune system phenotype ( J:120069 )

N • OVA-induced tissue accumulation of eosinophils is normal