Analysis Tools
mortality/aging
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• die at around E10.5
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growth/size/body
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• embryos show a pronounced delay in posterior development, with some showing incomplete embryonic turning
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embryo
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• blood vessels fail to invade the placental labyrinth
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• seen in some embryos
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• at E9.5, embryos display growth arrest at the 16-to 20-somite stage
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• embryos show a pronounced delay in posterior development, with some showing incomplete embryonic turning
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• the forebrain neural tube is degenerated, with abundant pyknotic and fragmented nuclei
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• somites are poorly defined, with signs of apoptosis
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• embryos fail to remodel the primary vascular plexus to form large and small blood vessels of the mature yolk sac
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cardiovascular system
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• intersomitic blood vessels are poorly defined, with signs of apoptosis
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• blood vessels fail to invade the placental labyrinth
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• exhibit a marked reduction in vessel organization and a persistent, immature vascular plexus, suggesting a block in vascular maturation and angiogenic remodeling
• intact vasculogenesis but impaired secondary angiogenic sprouting and remodeling
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• embryos show a decreased number of branching blood vessels throughout the embryo
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• the anterior cardinal vein appears hypoplastic
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• the heart displays delayed looping beginning at E9.5
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• pericardial effusion is seen at E9.5 but not earlier
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hemorrhage
(
J:100449
)
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• starting at E9.5, there is intraembryonic hemorrhage into the pericardium and tails
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• starting at E9.5, there is intraembryonic hemorrhage into the pericardium
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nervous system
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• the forebrain neural tube is degenerated, with abundant pyknotic and fragmented nuclei
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cellular
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• widespread apoptosis in neural cells and the inner endothelial lining of the aorta
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homeostasis/metabolism
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• pericardial effusion is seen at E9.5 but not earlier
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• starting at E9.5, there is intraembryonic hemorrhage into the pericardium
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muscle
