Analysis Tools
mortality/aging
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• mean survival time is 307 days compared to over 600 for control mice
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growth/size/body
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• there is a significant drop in body weight as mice age
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behavior/neurological
digestive/alimentary system
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• occurs in these mice as the age
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• rectal prolapse and anal bleeding occurs in some mice as they age
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hematopoietic system
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• leukocytes transgress postcapillary venules at a much slower rate in LPS exposed tissue
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• leukocytes adhere to postcapillary venules without migrating through leading to significant accumulation
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• reduced numbers of eosinophils in airway lumen of antigen challenged mice
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• significant increase in peripheral blood
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• increase in number of neutrophils in the peripheral blood
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• 2 fold increase in number of lymphocytes in the peripheral blood
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• about 2 fold increase in number of monocytes in peripheral blood
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• eosinophil migration out of blood vessels is hindered
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• activated T cells show no chemotactic response in vitro to various concentrations of CXCR3 ligands CXCL9, CXCL10, or CXCL11, while wild-type cells show a weak response to CXCL9, and mount vigorous responses to CXCL10 and CXCL11; GTPgammaS membrane incorporation by mutant cells is absent in response to CXCR3 ligands
• CXCL12-evoked chemotactic responses are diminished compared to wild-type controls
• cells show similar response as controls in response to CCL19 or CCL21
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immune system
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• leukocytes transgress postcapillary venules at a much slower rate in LPS exposed tissue
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• leukocytes adhere to postcapillary venules without migrating through leading to significant accumulation
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• reduced numbers of eosinophils in airway lumen of antigen challenged mice
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• significant increase in peripheral blood
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• increase in number of neutrophils in the peripheral blood
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• 2 fold increase in number of lymphocytes in the peripheral blood
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• about 2 fold increase in number of monocytes in peripheral blood
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• eosinophil migration out of blood vessels is hindered
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• activated T cells show no chemotactic response in vitro to various concentrations of CXCR3 ligands CXCL9, CXCL10, or CXCL11, while wild-type cells show a weak response to CXCL9, and mount vigorous responses to CXCL10 and CXCL11; GTPgammaS membrane incorporation by mutant cells is absent in response to CXCR3 ligands
• CXCL12-evoked chemotactic responses are diminished compared to wild-type controls
• cells show similar response as controls in response to CCL19 or CCL21
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cellular
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• leukocytes transgress postcapillary venules at a much slower rate in LPS exposed tissue
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• leukocytes adhere to postcapillary venules without migrating through leading to significant accumulation
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