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Phenotypes Associated with This Genotype
Genotype
MGI:3710684
Allelic
Composition		 Gnai3tm1Lbi/Gnai3tm1Lbi
Genetic
Background		 B6.129S-Gnai3tm1Lbi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai3tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:121161 )
• activated T cells show dramatically increased response to CXCL9 and CXCL11, and a lesser increased response to CXCL10 in vitro, relative to wild-type cells; GTPgammaS membrane incorporation is significantly increased in response to CXCR3 agonist stimulation, correlating with enhanced chemotaxis
• CXCL12-evoked chemotactic responses are diminished compared to wild-type controls

hematopoietic system
abnormal T cell physiology ( J:121161 )
• activated T cells show dramatically increased response to CXCL9 and CXCL11, and a lesser increased response to CXCL10 in vitro, relative to wild-type cells; GTPgammaS membrane incorporation is significantly increased in response to CXCR3 agonist stimulation, correlating with enhanced chemotaxis
• CXCL12-evoked chemotactic responses are diminished compared to wild-type controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory