About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3711186
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Genetic
Background
B6.129S2-Casp1tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (42 available)
Casp4del mutation (5 available); any Casp4 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• reduced compared to controls after LPS induced acute kidney failure but not significantly
• reduced after LPS induced acute kidney failure but less than in controls
• LPS induced acute kidney failure is also less severe

digestive/alimentary system
• mice and co-housed wild-type mice exhibit expanded bacterial phylotypes compared with wild-type mice
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice

immune system
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice
• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory