Phenotypes Associated with This Genotype

Genotype
MGI:3711514

• Allelic Composition: Cxadr^tm1Mds/Cxadr^tm1Mds; Tg(Tnnt2-cre)5Blh/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:121400 )

• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadr^tm1.1Mds homozygotes

cardiovascular system

abnormal cardinal vein morphology ( J:121400 )

• at E10.5, engorgement of the cardinal veins is apparent

abnormal heart tube morphology ( J:121400 )

• hyperplasia of proximal heart tube is seen at E10.5

absent sinoatrial valve ( J:121400 )

• sinuatrial valves, located at the junction between sinus venosus and atrium in wild-type embryos, are absent