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Phenotypes Associated with This Genotype
Genotype
MGI:3711877
Allelic
Composition		 Gas1tm2Fan/Gas1tm2Fan
Shhtm1Chg/Shh+
Genetic
Background		 involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas1tm2Fan mutation (0 available); any Gas1 mutation (14 available)
Shhtm1Chg mutation (2 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
oligodactyly ( J:121554 )
• 16% of forelimbs have 4.5 digits, 84% of forelimbs and 100% of hindlimbs are missing digit 2
• no digit forms at the digit 2 position

nervous system
holoprosencephaly ( J:121554 )
• mild, with a narrowing and fusion of the midline facial structures

respiratory system
single external naris ( J:121554 )
• single nostril

craniofacial
single external naris ( J:121554 )
• single nostril

growth/size/body
single external naris ( J:121554 )
• single nostril

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory