Phenotypes Associated with This Genotype

Genotype
MGI:3711905

• Allelic Composition: Gli3^tm2Blnw/Gli3^tm2Blnw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:121609 )

• mice die mostly before birth and those that are born die soon after

limbs/digits/tail

abnormal digit morphology ( J:121609 )

• at birth, all of the digits consist of only two very short phalanges with the proximal ones being split with abnormal ossification

abnormal phalanx morphology ( J:121609 )

• at E16.5, in some mice phalanges lack ossification

• at birth, phalanges are short and proximal ones are split

• extra phalanges element branch from the metatarsals

polydactyly ( J:121609 )

• at E16.5, mice have 6 to 8 digits that lack identity

absent tibia ( J:121609 )

• at E16.5

short tibia ( J:121609 )

• when present, tibia is shorter

skeleton

abnormal phalanx morphology ( J:121609 )

• at E16.5, in some mice phalanges lack ossification

• at birth, phalanges are short and proximal ones are split

• extra phalanges element branch from the metatarsals

absent tibia ( J:121609 )

• at E16.5

short tibia ( J:121609 )

• when present, tibia is shorter

synostosis ( J:121609 )

• at E16.5, in some mice a ring-shaped ossification forms interdigitally

• at birth ossification between digits is located between the distal phalanges