Phenotypes Associated with This Genotype

Genotype
MGI:3712869

• Allelic Composition: Gnai2^tm1.1Rneu/Gnai2^tm1.1Rneu
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:121385 )

• injection of carbachol lead to the death of one mouse

premature death ( J:121385 )

• mice exhibit reduced viability

cardiovascular system

decreased heart rate ( J:121385 )

• 5.1-fold enhancement in muscarinic-induced bradcycardic response

• carbachol injection results in severe bradycardia

• however, adenosine-induced bradcycardic response is not significantly different

increased heart rate ( J:121385 )

• procaterol-induced tachycardia is significantly attenuated at high doses

• however, there is a slightly negative chronotropic response to procaterol at low doses

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:121385 )

• injection of carbachol lead to the death of one mouse

increased physiological sensitivity to xenobiotic ( J:121385 )

• 5.1-fold enhancement in muscarinic-induced bradcycardic response

• carbachol injection results in severe bradycardia

• procaterol-induced tachycardia is significantly attenuated at high doses

• however, adenosine-induced bradcycardic response is not significantly different

• however, there is a slightly negative chronotropic response to procaterol at low doses

growth/size/body

decreased body weight ( J:121385 )

• homozygotes show reduced body weight relative to controls