Phenotypes Associated with This Genotype

Genotype
MGI:3713241

• Allelic Composition: Efnb1^tm1Rha/Efnb1⁺; Tg(Pgk1-cre)1Lni/?
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:110732 )

♀ • only 1-2% of females survived past weaning

skeleton

abnormal carpal bone morphology ( J:110732 )

♀ • ectopic ossifications form in 1 of 5 adults

fused carpal bones ( J:110732 )

♀ • distal carpal bones are fused

asymmetric rib joints ( J:110732 )

♀ • at E18.5, in 3 of 8 mice and to a lesser extent than in hemizygous Efnb1^tm1Rha Tg(Pgk1-cre)1Lni males

abnormal cartilage development ( J:110732 )

♀ • cartilages corresponding to the distal carpal bones are delayed or sometimes impaired

limbs/digits/tail

abnormal carpal bone morphology ( J:110732 )

♀ • ectopic ossifications form in 1 of 5 adults

fused carpal bones ( J:110732 )

♀ • distal carpal bones are fused

polydactyly ( J:110732 )

♀ • 75% of females exhibit polydactyly

growth/size/body

omphalocele ( J:110732 )

♀ • at E14.5, the body wall is incompletely closed in all embryosat E14.5, the body wall is incompletely closed in all embryos