mortality/aging
• double heterozygous mice that carry the Myf5 and Myf6 alleles on different chromosomes and express drastically reduced levels of Myf5 mRNA do not survive to weaning and when delivered by cesarean section at E18.5, the pups die within a few minutes after delivery
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skeleton
short ribs
(
J:31636
)
• mutants lack the distal parts of the ribs
• the average rib length is between that of Myf6 and Myf5 homozygotes
|