Phenotypes Associated with This Genotype

Genotype
MGI:3714407

• Allelic Composition: Myf5^tm1Jae/Myf5⁺; Myf6^tm1Wb/Myf6⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:42453 )

• double heterozygous mice in which the Myf5 and Myf6 alleles are on different chromosomes show severely reduced expression of Myf5 and die at birth due to respiratory distress

respiratory system

respiratory distress ( J:42453 )

skeleton

abnormal sternebra morphology ( J:42453 )

• sternum shows irregular ossification of sternebrae

abnormal sternocostal joint morphology ( J:42453 )

• none of the first seven ribs are attached to the sternum

abnormal rib morphology ( J:42453 )

rib bifurcation ( J:42453 )

rib fusion ( J:42453 )

• fusion of adjacent ribs

short ribs ( J:42453 )

• short ribs; ribs are shorter than in wild-type or Myf6 homozygotes but longer than the stubs of Myf5 homozygotes

muscle

abnormal myotome development ( J:42453 )

• myotomes are disorganized at E10.5